| 1 | Noah Dahlman | US | Landstede Hammers MSE 1 | 2021-2022 | 642 | 34 | 18.88 |
| 2 | Kiki Fleuren | NL | Den Helder SUNS VSE 1 | 2021-2022 | 551 | 31 | 17.77 |
| 3 | Asbjorn Midtgaard | DK | Zorg en Zekerheid Leiden MSE 1 | 2021-2022 | 550 | 37 | 14.86 |
| 4 | Ben Kovac | LU | Den Helder SUNS MSE 1 | 2021-2022 | 548 | 34 | 16.12 |
| 5 | Jarrid Rhodes | US | Feyenoord Basketball MSE 1 | 2021-2022 | 545 | 35 | 15.57 |
| 6 | Jhonathan Dunn | US | Zorg en Zekerheid Leiden MSE 1 | 2021-2022 | 535 | 38 | 14.08 |
| 7 | Duane Wilson | US | Yoast United MSE 1 | 2021-2022 | 509 | 30 | 16.97 |
| 8 | Marlou de Kleijn | NL | Startportaal Binnenland VSE 1 | 2021-2022 | 503 | 24 | 20.96 |
| 9 | Edon Maxhuni | FI | Heroes Den Bosch MSE 1 | 2021-2022 | 502 | 37 | 13.57 |
| 10 | Kourtney Treffers | NL | Den Helder SUNS VSE 1 | 2021-2022 | 499 | 26 | 19.19 |
| 11 | Cairon Jones | US | Feyenoord Basketball MSE 1 | 2021-2022 | 496 | 34 | 14.59 |
| 12 | George Michael Phillip Brock | US | Aris Leeuwarden MSE 1 | 2021-2022 | 488 | 38 | 12.84 |
| 13 | Naba Echols | US | Landstede Hammers MSE 1 | 2021-2022 | 487 | 36 | 13.53 |
| 14 | Marquis Addison | US | Donar Groningen MSE 1 | 2021-2022 | 485 | 37 | 13.11 |
| 15 | Christopher Hudson | US | Basketbal Academie Limburg MSE 1 | 2021-2022 | 465 | 32 | 14.53 |
| 16 | Ryan Patrick Logan | US | Aris Leeuwarden MSE 1 | 2021-2022 | 463 | 38 | 12.18 |
| 17 | Lisanne de Jonge | NL | Lekdetec.nl VSE 1 | 2021-2022 | 462 | 23 | 20.09 |
| 18 | Tibor Taras | DE | BC APOLLO Amsterdam MSE 1 | 2021-2022 | 445 | 30 | 14.83 |
| 19 | Janine Guijt | NL | Startportaal Binnenland VSE 1 | 2021-2022 | 438 | 25 | 17.52 |
| 20 | Stan van den Elzen | NL | Den Helder SUNS MSE 1 | 2021-2022 | 433 | 32 | 13.53 |
| 21 | Thomas Van der Mars | NL | Heroes Den Bosch MSE 1 | 2021-2022 | 424 | 36 | 11.78 |
| 22 | Austin Price | US | Heroes Den Bosch MSE 1 | 2021-2022 | 422 | 34 | 12.41 |
| 23 | Sander Hollanders | NL | Basketbal Academie Limburg MSE 1 | 2021-2022 | 421 | 33 | 12.76 |
| 24 | Einaras Tubutis | LT | Zorg en Zekerheid Leiden MSE 1 | 2021-2022 | 420 | 37 | 11.35 |
| 25 | Jett Speelman | US | Yoast United MSE 1 | 2021-2022 | 418 | 31 | 13.48 |
| 26 | Ralf de Pagter | NL | Landstede Hammers MSE 1 | 2021-2022 | 414 | 31 | 13.35 |
| 27 | Addy Clift | US | Martini Sparks VSE 1 | 2021-2022 | 412 | 21 | 19.62 |
| 28 | Michael Carlson | US | Heroes Den Bosch MSE 1 | 2021-2022 | 410 | 29 | 14.14 |
| 29 | Nate Britt | US | Yoast United MSE 1 | 2021-2022 | 410 | 32 | 12.81 |
| 30 | Janis Ndiba - Boonstra | NL | Den Helder SUNS VSE 1 | 2021-2022 | 388 | 32 | 12.12 |
| 31 | Arunas Mikalauskas | LT | Zorg en Zekerheid Leiden MSE 1 | 2021-2022 | 383 | 32 | 11.97 |
| 32 | Quin Cooper | US | Aris Leeuwarden MSE 1 | 2021-2022 | 380 | 38 | 10.00 |
| 33 | Charlotte van Kleef | NL | Landslake Lions VSE 1 | 2021-2022 | 371 | 24 | 15.46 |
| 34 | Nigel Pruitt | US | Aris Leeuwarden MSE 1 | 2021-2022 | 371 | 24 | 15.46 |
| 35 | Clay Mounce | US | Heroes Den Bosch MSE 1 | 2021-2022 | 371 | 37 | 10.03 |
| 36 | Coen Stolk | NL | Feyenoord Basketball MSE 1 | 2021-2022 | 367 | 35 | 10.49 |
| 37 | Dragos Diculescu | RO | Landstede Hammers MSE 1 | 2021-2022 | 364 | 30 | 12.13 |
| 38 | Janiek van Veen | NL | Den Helder SUNS VSE 1 | 2021-2022 | 363 | 30 | 12.10 |
| 39 | Luuk van Bree | NL | Zorg en Zekerheid Leiden MSE 1 | 2021-2022 | 361 | 37 | 9.76 |
| 40 | Jeroen van de List | NL | Feyenoord Basketball MSE 1 | 2021-2022 | 358 | 31 | 11.55 |
| 41 | Kaleb Warner | US | Yoast United MSE 1 | 2021-2022 | 355 | 32 | 11.09 |
| 42 | Wietze Nossek | NL | Basketbal Academie Limburg MSE 1 | 2021-2022 | 353 | 33 | 10.70 |
| 43 | Eline Kasius | NL | Startportaal Binnenland VSE 1 | 2021-2022 | 351 | 24 | 14.62 |
| 44 | Noor Driessen | NL | Sportiff Company Grasshoppers VSE 1 | 2021-2022 | 351 | 29 | 12.10 |
| 45 | Sam Huurman | NL | Den Helder SUNS MSE 1 | 2021-2022 | 345 | 29 | 11.90 |
| 46 | Jose Dimitri Maconda | NL | Aris Leeuwarden MSE 1 | 2021-2022 | 344 | 36 | 9.56 |
| 47 | Kim Jaasma | NL | Martini Sparks VSE 1 | 2021-2022 | 341 | 21 | 16.24 |
| 48 | Donovan Mitchell | US | Basketbal Academie Limburg MSE 1 | 2021-2022 | 339 | 21 | 16.14 |
| 49 | Tom Ackermans | NL | BV The Hague Royals MSE 1 | 2021-2022 | 338 | 32 | 10.56 |
| 50 | Roger Moute A Bidias | US | BC APOLLO Amsterdam MSE 1 | 2021-2022 | 333 | 21 | 15.86 |